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44 references. Guidelines for care, original studies for specific findings, and the limits of each one written down.

For pages that are updated all the time, the year may be the year we looked at them. Our “how well proven” labels are our own simple labels, not an official grading. Read how we work →

44 sources

Symptoms & Causes of Diabetes (opens in a new tab)

NIH / NIDDK · 2026 · Reference

Established
Who was studied, limits and source check

Limitations: Access year shown. Symptoms overlap with many conditions and cannot establish diabetes type.

Source checked 2026-09-30. See the original publication for full methods.

Diabetic Eye Disease (opens in a new tab)

NIH / NIDDK · 2026 · Reference

Established
Who was studied, limits and source check

Limitations: Access year shown. Screening intervals and treatments depend on clinical findings.

Source checked 2026-09-30. See the original publication for full methods.

Diabetic Kidney Disease (opens in a new tab)

NIH / NIDDK · 2026 · Reference

Established
Who was studied, limits and source check

Limitations: Access year shown. Other kidney diseases can coexist; a single abnormal result is not a complete diagnosis.

Source checked 2026-09-30. See the original publication for full methods.

VX-264 Phase 1/2 study registration (opens in a new tab)

ClinicalTrials.gov; Vertex Pharmaceuticals · 2026 · Early human study

Experimental
Who was studied, limits and source check

Limitations: Registry accessed in 2026. Enrollment and registration are not proof of efficacy; consult the live record for recruitment and results.

Source checked 2026-09-30. See the original publication for full methods.

Diabetes Technology: Standards of Care 2026 (opens in a new tab)

American Diabetes Association · 2026 · Guideline

Strong Evidence
Who was studied, limits and source check

Limitations: Access, training, device labeling, and safe-use capacity affect applicability.

Source checked 2026-09-30. See the original publication for full methods.

Children and Adolescents: Standards of Care 2026 (opens in a new tab)

American Diabetes Association · 2026 · Guideline

Established
Who was studied, limits and source check

Limitations: Pediatric care requires developmental and family context; adult thresholds do not define a complete care plan.

Source checked 2026-09-30. See the original publication for full methods.

Diabetes Tests & Diagnosis (opens in a new tab)

NIH / NIDDK · 2026 · Reference

Established
Who was studied, limits and source check

Limitations: Living patient resource; year denotes access year, not a newly published study.

Source checked 2026-09-30. See the original publication for full methods.

The A1C Test & Diabetes (opens in a new tab)

NIH / NIDDK · 2026 · Reference

Established
Who was studied, limits and source check

Limitations: Living reference accessed in 2026; red-cell disorders can make A1c unreliable.

Source checked 2026-09-30. See the original publication for full methods.

Insulin Resistance & Prediabetes (opens in a new tab)

NIH / NIDDK · 2026 · Reference

Established
Who was studied, limits and source check

Limitations: Access year is shown; population risk factors do not establish an individual diagnosis.

Source checked 2026-09-30. See the original publication for full methods.

FDA accelerated approval: teplizumab in selected recently diagnosed pediatric Stage 3 T1D (opens in a new tab)

US Food and Drug Administration · 2026 · Regulatory

Strong Evidence
Who was studied, limits and source check

Population: Children aged 8–17 recently diagnosed with Stage 3 T1D

Sample: PROTECT: 328 participants

Limitations: June 12 accelerated approval based on C-peptide preservation, a surrogate. Confirmatory clinical benefit and label conditions matter.

Source checked 2026-09-30. See the original publication for full methods.

Tzield prescribing information, revised June 2026 (opens in a new tab)

US Food and Drug Administration · 2026 · Regulatory

Established
Who was studied, limits and source check

Limitations: US label. Age and staging criteria differ between indications; specialist evaluation and infection precautions are required.

Source checked 2026-09-30. See the original publication for full methods.

Pathogenesis of Type 2 Diabetes Mellitus (opens in a new tab)

Endotext / NCBI Bookshelf · 2026 · Review

Established
Who was studied, limits and source check

Limitations: Multiple pathways coexist; one explanatory model does not capture every T2D phenotype.

Source checked 2026-09-30. See the original publication for full methods.

The discovery of insulin (opens in a new tab)

Nobel Prize educational archive · 2026 · Reference

Established
Who was studied, limits and source check

Limitations: Historical educational account accessed in 2026; not a clinical evidence source.

Source checked 2026-09-30. See the original publication for full methods.

Cagrilintide–Semaglutide in Adults with Overweight or Obesity and T2D (opens in a new tab)

REDEFINE 2 Study Group; New England Journal of Medicine · 2025 · Randomized trial

Strong Evidence
Who was studied, limits and source check

Population: Adults with BMI ≥27, T2D and HbA1c 7–10%

Sample: 1,206 randomized participants

Limitations: 68-week trial; weight and glycemia outcomes are not evidence of a permanent cure. Publication does not establish regulatory approval.

Source checked 2026-09-30. See the original publication for full methods.

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes (opens in a new tab)

Reichman et al.; New England Journal of Medicine · 2025 · Early human study

Preliminary
Who was studied, limits and source check

Population: Selected adults with T1D, severe hypoglycemia and impaired awareness

Sample: 14 with ≥12-month follow-up; 12 at full dose

Limitations: Small, uncontrolled interim analysis; required immunosuppression; serious adverse events and deaths occurred. Not a routine cure.

Source checked 2026-09-30. See the original publication for full methods.

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression (opens in a new tab)

Carlsson et al.; New England Journal of Medicine · 2025 · Early human study

Experimental
Who was studied, limits and source check

Population: One adult with long-standing T1D

Sample: 1 participant; 12-week reported follow-up

Limitations: Single participant, low cell dose and short follow-up. Does not demonstrate generalizable insulin independence.

Source checked 2026-09-30. See the original publication for full methods.

Tirzepatide for Obesity Treatment and Diabetes Prevention (opens in a new tab)

Jastreboff et al.; New England Journal of Medicine · 2025 · Randomized trial

Strong Evidence
Who was studied, limits and source check

Population: Adults with obesity and prediabetes

Sample: 1,032 in the prediabetes analysis

Limitations: 176-week treatment and limited off-treatment follow-up; manufacturer-funded; prevention during therapy is not a permanent cure.

Source checked 2026-09-30. See the original publication for full methods.

Diabetic Ketoacidosis (opens in a new tab)

US Centers for Disease Control and Prevention · 2024 · Reference

Established
Who was studied, limits and source check

Limitations: General patient education, not a substitute for emergency assessment.

Source checked 2026-09-30. See the original publication for full methods.

Five-year follow-up of the Diabetes Remission Clinical Trial (DiRECT) (opens in a new tab)

Lean et al.; The Lancet Diabetes & Endocrinology · 2024 · Cohort

Moderate Evidence
Who was studied, limits and source check

Population: UK adults with relatively recent T2D; selected extension participants

Sample: 85 extension participants assessed at 5 years

Limitations: Extension cohort selection and attrition; 13% is not the remission probability for all people with diabetes.

Source checked 2026-09-30. See the original publication for full methods.

Diabetes — WHO fact sheet (opens in a new tab)

World Health Organization · 2024 · Population study

Strong Evidence
Who was studied, limits and source check

Population: Global population; adult prevalence estimates

Limitations: Modeled estimates for 1990 and 2022; count, prevalence, incidence, and deaths are distinct measures.

Source checked 2026-09-30. See the original publication for full methods.

FDA approves first donor islet cellular therapy for selected adults with T1D (opens in a new tab)

US Food and Drug Administration · 2023 · Regulatory

Strong Evidence
Who was studied, limits and source check

Population: Adults with T1D and repeated severe hypoglycemia despite intensive management

Sample: 30 in two nonrandomized single-arm studies

Limitations: Selected population, donor constraints and risks of infusion and immunosuppression. Approval does not establish universal cure.

Source checked 2026-09-30. See the original publication for full methods.

Chronic Insufficient Sleep in Women Impairs Insulin Sensitivity: Randomized Trial (opens in a new tab)

Diabetes Care; Columbia University investigators · 2023 · Randomized trial

Moderate Evidence
Who was studied, limits and source check

Population: Women studied under experimentally restricted sleep

Limitations: Six-week physiological study; insulin sensitivity is a surrogate and the study does not establish long-term diabetes incidence.

Source checked 2026-09-30. See the original publication for full methods.

ICMR-INDIAB-17 national metabolic disease survey (opens in a new tab)

Anjana et al.; The Lancet Diabetes & Endocrinology · 2023 · Population study

Strong Evidence
Who was studied, limits and source check

Population: Adults aged ≥20 across India

Sample: 113,043 participants surveyed during 2008–2020

Limitations: Cross-sectional estimates; survey timing varied by state and findings are not individual predictions.

Source checked 2026-09-30. See the original publication for full methods.

Evaluation of the Indian Diabetes Risk Score in ICMR-INDIAB (opens in a new tab)

Deepa et al.; Indian Journal of Medical Research · 2023 · Population study

Moderate Evidence
Who was studied, limits and source check

Population: Urban and rural India

Sample: 113,043 surveyed individuals

Limitations: Screening for undiagnosed diabetes is distinct from predicting incident disease; external calibration remains important.

Source checked 2026-09-30. See the original publication for full methods.

Physiology, Glucose Transporter Type 4 (opens in a new tab)

StatPearls / NCBI Bookshelf · 2023 · Reference

Established
Who was studied, limits and source check

Limitations: Educational reference; transport pathways vary by tissue and experimental context.

Source checked 2026-09-30. See the original publication for full methods.

Drug Trials Snapshot: Tzield original approval (opens in a new tab)

US Food and Drug Administration · 2022 · Randomized trial

Strong Evidence
Who was studied, limits and source check

Population: High-risk relatives with presymptomatic T1D

Sample: 76 participants in TN-10

Limitations: Original evidence concerns delay of Stage 3, not prevention for everyone; see the current label for updated eligibility.

Source checked 2026-09-30. See the original publication for full methods.

Diabetes Prevention Program: trial and follow-up (opens in a new tab)

NIH / NIDDK; DPP Research Group · 2002 · Randomized trial

Strong Evidence
Who was studied, limits and source check

Population: US adults at high risk with elevated glucose and overweight

Sample: 3,234 randomized adults

Limitations: Relative risk reductions over about 3 years; not a guarantee for every individual or every prediabetes definition.

Source checked 2026-09-30. See the original publication for full methods.